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Preliminary meeting of Adipoplast plus in Tarragona

By Adipoplast | Sin categoría | 0 comment | 12 abril, 2018 | 0

On occasion of the DIAMET workshop, organized by the Adipoplast team leaded by Sonia Ferández-Veledo and Joan Vendrell, five member teams of the network (J.M Fernández-Real, M.M. Malagón, G.Fruhbeck, F.Villarroya) met and discussed preliminary actions for the second period of activitties of the network, programmed thanks to the recent funding by MINECO

Renewed support to the Adipoplast network of excellence by MINECO

By Adipoplast | Sin categoría | 0 comment | 12 abril, 2018 | 0

The application for a further two-year support to our network (Adipoplast plus) has been awarded by MINECO ( BFU2017-90578-REDT). Network activities in the next two years will be improved and expanded thanks to the incorporation of  two new research teams: the laboratory by Beatriz Gálvez devoted to adipose tissue stem cells research, and the laboratory leadedLeer Más

Workshop on Infrared thermography for brown fat activity estimation in humans.

By Adipoplast | Sin categoría | 0 comment | 22 noviembre, 2017 | 1

Workshop (Link program) Adipoplast, with the collaboration of IBUB, organizes a workshop on the use of infrared thermography to estimate brown adipose tissue activity in humans. Invited experts from the University of Granada, University of Cadiz, and Institut de Recerca Germans Trias i Pujol, Badalona, will attend the meeting, in addition to Adipoplast members, will discussLeer Más

Adipoplast meeting on occasion of the 59 Congress of Sociedad Española de Endocrinología y Nutrición, in Barcelona.

By Adipoplast | Sin categoría | 0 comment | 23 octubre, 2017 | 0

Adipoplast researchers from most of the laboratories of the network met in Barcelona to reinforce internal and external collaborations on occasion of the SEEN meeting. Moreover, members of the Adipoplast network presented collaborative works to the conference, in fields ranging from new mechanisms of regulation of adipocyte biology to advances in the study of theLeer Más

The four research teams of Adipoplast belonging to CIBERobn obtain an intramural research project to use next generation genomics to profile gene expression in human adipose tissue in obesity.

By Adipoplast | Sin categoría | 0 comment | 15 octubre, 2017 | 0

The four research teams of Adipoplast belonging to CIBERobn obtain an intramural research project to use next generation genomics to profile gene expression in human adipose tissue in obesity. Under the coordination of Francesc Villarroya (University of Barcelona), the teams leaded by M.M.Malagón (University of Córdoba), Gema Fruhbeck/Amaia Rodríguez (Clínica Universitaria de Navarra), and José M.Leer Más

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Última Publicación

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F ,Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Cell Metab. 2017;26:212-229.

Abstract:

Thyroid hormones (THs) act in the brain to modulate energy balance. We show that central triiodothyronine (T3) regulates de novo lipogenesis in liver and lipid oxidation in brown adipose tissue (BAT) through the parasympathetic (PSNS) and sympathetic nervous system (SNS), respectively. Central T3 promotes hepatic lipogenesis with parallel stimulation of the thermogenic program in BAT. The action of T3 depends on AMP-activated protein kinase (AMPK)-induced regulation of two signaling pathways in the ventromedial nucleus of the hypothalamus (VMH): decreased ceramide-induced endoplasmic reticulum (ER) stress, which promotes BAT thermogenesis, and increased c-Jun N-terminal kinase (JNK) activation, which controls hepatic lipid metabolism. Of note, ablation of AMPKα1 in steroidogenic factor 1 (SF1) neurons of the VMH fully recapitulated the effect of central T3, pointing to this population in mediating the effect of central THs on metabolism. Overall, these findings uncover the underlying pathways through which central T3 modulates peripheral metabolism.

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