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A collaborative work involving two Adipoplast laboratories reports the discovery of a new mechanism for regulating the metabolism of brown adipose tissue through the hormonal system kallikrein-kinin system.

By Adipoplast | Sin categoría | Comments are Closed | 4 May, 2020 | 0

That system, in which bradykinin is a main actor, has been traditionally associated with the physiology of the renal and cardiovascular systems and processes of inflammation and pain. Researchers report the kallikrein-kinin system acts as mechanism of molecular self-control of brown and beige adipose tissue thermogenic activation, and could help prevent the harmful effects of excessive activation ofLeer Más

A collaborative study lead by Sonia Fernàndez-Veledo from the ADIPOPLAST team at Institut d’Investigació Sanitària Pere Virgili, Hospital Universitari de Tarragona Joan XXIII, identifies the preoperative circulating succinate levels as biomarker for diabetes remission after bariatric surgery.

By Adipoplast | Sin categoría | Comments are Closed | 8 March, 2020 | 0

The study has been published in Diabates Care, a leading journal of the American Diabates association, and has been participated by two other  ADIPOPLAST teams lead by José Manuel Fernández Real (Hospital Josep Trueta, Girona), and Amaia Rodriguez (Clinica Universidad de Navarra), also members of ADIPOPLAST. The publication reports the predictive value of succinate levelsLeer Más

Central nicotine induces browning through hypothalamic κ opioid receptor, and may be a target against human obesity.

By Adipoplast | Sin categoría | 0 comment | 18 September, 2019 | 0

The three members of Adipoplast plus leaded by M.A.López CIMUS and Unversity of Santiago de Compostela), J.M.Fernández-Real (Hospital Josep Trueta, Girona) and G.Medina (Universidad Rey Juan Carlos, Madrid) publish a collaborative study in Nature Communications (Nat Commun. 2019; 10: 4037. doi: 10.1038/s41467-019-12004-z)  showing that nicotine induces the browning of white adipose tissue through a central mechanism and thatLeer Más

Adipoplast research teams identify TAGLN2 as a protein expressed in adipose tissue and associated with obesity and inflammation, being normalized upon weight loss

By Adipoplast | Sin categoría | 0 comment | 9 August, 2019 | 0

The three Adipoplast research teams leaded by JM Fernández-Real (Hospital Josep Trueta, Girona), M.M.Malagón (University of Córdoba) and G.Fruhbeck (University of Navarra) have identified, thanks to a collaborative study, the important contribution of cytoskeletal TAGLN2 protein to the obese phenotype in a gender-dependent manner, in a recent publication in FASEB Journal. For further information see: https://www.fasebj.org/doi/abs/10.1096/fj.201900479R?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=fasebj.

Nature Immunology reports the identification of succinate signaling in adipose tissue inflammation by the team leaded by Sonia Fernández-Veledo and Joan Vendrell, at Hospital Joan XXIII, Tarragona, with the collaboration of Gema Medina (Universidad Rey Juan Carlos), all them members of the Adipoplast network.

By Adipoplast | Sin categoría | 0 comment | 16 April, 2019 | 0

The study highlights the importance of succinate signaling through the SUCNR1 receptor in determining macrophage polarization and assigns a role to succinate in limiting inflammation in adipose tissue.This is a key finding for improving our understanding of the pathophysiology of adipose tissue in obesity and other metabolic diseases.  For more details see: https://www.ncbi.nlm.nih.gov/pubmed/30962591

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Last publication

Seoane-Collazo P, Liñares-Pose L, Rial-Pensado E, Romero-Picó A, Moreno-Navarrete JM,
Martínez-Sánchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-García JL, Nogueiras R, Domingos AI, Fernández-Real JM, Rahmouni K, Diéguez C, López M.

Central nicotine induces browning through hypothalamic κ opioid receptor.

Nat Commun. 2019 Sep 6;10(1):4037. doi: 10.1038/s41467-019-12004-z.


Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding and energy expenditure at the central level. Among the central actions of nicotine on body weight, much attention has been focused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue (WAT) is unclear. Here, we show that nicotine induces the browning of WAT through a central mechanism and that this effect is dependent on the κ opioid receptor (KOR), specifically in the lateral hypothalamic area (LHA). Consistent with these findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which correlates with smoking status. These data demonstrate that central nicotine-induced modulation of WAT browning may be a target against human obesity.

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