AdipoplastAdipoplastAdipoplastAdipoplast
  • Home
  • About us
  • Research groups
  • Database
  • Contact

A collaborative study lead by Sonia Fernàndez-Veledo from the ADIPOPLAST team at Institut d’Investigació Sanitària Pere Virgili, Hospital Universitari de Tarragona Joan XXIII, identifies the preoperative circulating succinate levels as biomarker for diabetes remission after bariatric surgery.

    Home Sin categoría A collaborative study lead by Sonia Fernàndez-Veledo from the ADIPOPLAST team at Institut d’Investigació Sanitària Pere Virgili, Hospital Universitari de Tarragona Joan XXIII, identifies the preoperative circulating succinate levels as biomarker for diabetes remission after bariatric surgery.

    A collaborative study lead by Sonia Fernàndez-Veledo from the ADIPOPLAST team at Institut d’Investigació Sanitària Pere Virgili, Hospital Universitari de Tarragona Joan XXIII, identifies the preoperative circulating succinate levels as biomarker for diabetes remission after bariatric surgery.

    By Adipoplast | Sin categoría | Comments are Closed | 8 March, 2020 | 0

    The study has been published in Diabates Care, a leading journal of the American Diabates association, and has been participated by two other  ADIPOPLAST teams lead by José Manuel Fernández Real (Hospital Josep Trueta, Girona), and Amaia Rodriguez (Clinica Universidad de Navarra), also members of ADIPOPLAST. The publication reports the predictive value of succinate levels for diabetes remission independently of previously described pre-surgical factors. This finding is a significant improvement upon the current available scores to predict diabetes remission. This study highlights the importance of succinate in metabolic control via several biological mechanisms, as previously reported by the Fernández-Veledo team, in collaboration with Gema Medina-Gómez (Universidad Rey Juan Carlos), leader of another ADIPOPLAST team as well, in a recent publication in Nature Immunology (Keiran N, et al. Nat Immunol 2019. PMID 30962591)

    No tags.

    Last publication

    Seoane-Collazo P, Liñares-Pose L, Rial-Pensado E, Romero-Picó A, Moreno-Navarrete JM,
    Martínez-Sánchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-García JL, Nogueiras R, Domingos AI, Fernández-Real JM, Rahmouni K, Diéguez C, López M.

    Central nicotine induces browning through hypothalamic κ opioid receptor.

    Nat Commun. 2019 Sep 6;10(1):4037. doi: 10.1038/s41467-019-12004-z.


    Increased body weight is a major factor that interferes with smoking cessation.
    Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding and energy expenditure at the central level. Among the central actions of nicotine on body weight, much attention has been focused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue (WAT) is unclear. Here, we show that nicotine induces the browning of WAT through a central mechanism and that this effect is dependent on the κ opioid receptor (KOR), specifically in the lateral hypothalamic area (LHA). Consistent with these findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which correlates with smoking status. These data demonstrate that central nicotine-induced modulation of WAT browning may be a target against human obesity.

    Copyright 2021 Adipoplast
    • Home
    • About us
    • Research groups
    • Database
    • Contact
    Adipoplast