That system, in which bradykinin is a main actor, has been traditionally associated with the physiology of the renal and cardiovascular systems and processes of inflammation and pain. Researchers report the kallikrein-kinin system acts as mechanism of molecular self-control of brown and beige adipose tissue thermogenic activation, and could help prevent the harmful effects of excessive activation ofLeer Más
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The study has been published in Diabates Care, a leading journal of the American Diabates association, and has been participated by two other ADIPOPLAST teams lead by José Manuel Fernández Real (Hospital Josep Trueta, Girona), and Amaia Rodriguez (Clinica Universidad de Navarra), also members of ADIPOPLAST. The publication reports the predictive value of succinate levelsLeer Más
The three members of Adipoplast plus leaded by M.A.López CIMUS and Unversity of Santiago de Compostela), J.M.Fernández-Real (Hospital Josep Trueta, Girona) and G.Medina (Universidad Rey Juan Carlos, Madrid) publish a collaborative study in Nature Communications (Nat Commun. 2019; 10: 4037. doi: 10.1038/s41467-019-12004-z) showing that nicotine induces the browning of white adipose tissue through a central mechanism and thatLeer Más
The three Adipoplast research teams leaded by JM Fernández-Real (Hospital Josep Trueta, Girona), M.M.Malagón (University of Córdoba) and G.Fruhbeck (University of Navarra) have identified, thanks to a collaborative study, the important contribution of cytoskeletal TAGLN2 protein to the obese phenotype in a gender-dependent manner, in a recent publication in FASEB Journal. For further information see: https://www.fasebj.org/doi/abs/10.1096/fj.201900479R?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=fasebj.
The study highlights the importance of succinate signaling through the SUCNR1 receptor in determining macrophage polarization and assigns a role to succinate in limiting inflammation in adipose tissue.This is a key finding for improving our understanding of the pathophysiology of adipose tissue in obesity and other metabolic diseases. For more details see: https://www.ncbi.nlm.nih.gov/pubmed/30962591
On the occasion of the SEEDO meeting in Vigo, the Adipolast coordinator and several Adipoplast representatives hold a meeting with the steering committe of SEEDO headed by Dr. Tinahones, president of SEEDO. Interchange of research perspectives on common interests were discussed and common, coordinated, actions for research of adiposity in the context of the obesityLeer Más
The Adipoplast network organized an open symposium on “The adipose tissue plasticity in health and disease” followed by an internal organizational meeting at “Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS)”, Santiago de Compostela, the last March 12th. Members of the Adipoplast network presented recent research advances as well as collaborative perspectives.Leer Más
Santiago de Compostela, March 12: next general Adipoplast Plus meeting Next March 12 will be the general Adipoplast Plus meeting at CIMUS, Santiago de Compostela. Research team members of the Adipoplast Plus network will present their research and discuss about coordinated activities. Dr. L. Fajas, University of Lausanne, Switzerland, and Dr. R. Nogueiras, CIMUS, researchersLeer Más
The Encyclopedia of Endocrine Diseases (2nd edition) publishes the chapter “Lipodystrophy” authores by Drs. F.Villarroya and Dra M. Giralt, from the University of Barcelona, and Dr. D. Araújo-Vilar from the University Clinical Hospital of Santiago de Compostela, all them members of the Adipoplast network.
The Adipoplast research teams leaded by M.López (CIMUS and University of Santiago de Compostela) and M.M.Malagón (University of Córdoba) participate in collaborative research identifying the role of p53 in AgRP neurons in adiposity. The study was published in Nature Communications last August. For further information see (full paper): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109113/