AdipoplastAdipoplastAdipoplastAdipoplast
  • Home
  • About us
  • Research groups
  • Database
  • Contact

Nature Immunology reports the identification of succinate signaling in adipose tissue inflammation by the team leaded by Sonia Fernández-Veledo and Joan Vendrell, at Hospital Joan XXIII, Tarragona, with the collaboration of Gema Medina (Universidad Rey Juan Carlos), all them members of the Adipoplast network.

    Home Sin categoría Nature Immunology reports the identification of succinate signaling in adipose tissue inflammation by the team leaded by Sonia Fernández-Veledo and Joan Vendrell, at Hospital Joan XXIII, Tarragona, with the collaboration of Gema Medina (Universidad Rey Juan Carlos), all them members of the Adipoplast network.

    Nature Immunology reports the identification of succinate signaling in adipose tissue inflammation by the team leaded by Sonia Fernández-Veledo and Joan Vendrell, at Hospital Joan XXIII, Tarragona, with the collaboration of Gema Medina (Universidad Rey Juan Carlos), all them members of the Adipoplast network.

    By Adipoplast | Sin categoría | 0 comment | 16 April, 2019 | 0

    The study highlights the importance of succinate signaling through the SUCNR1 receptor in determining macrophage polarization and assigns a role to succinate in limiting inflammation in adipose tissue.This is a key finding for improving our understanding of the pathophysiology of adipose tissue in obesity and other metabolic diseases.  For more details see: https://www.ncbi.nlm.nih.gov/pubmed/30962591

    No tags.

    Leave a Comment

    Cancel reply

    Your email address will not be published. Required fields are marked *

    Last publication

    Seoane-Collazo P, Liñares-Pose L, Rial-Pensado E, Romero-Picó A, Moreno-Navarrete JM,
    Martínez-Sánchez N, Garrido-Gil P, Iglesias-Rey R, Morgan DA, Tomasini N, Malone SA, Senra A, Folgueira C, Medina-Gomez G, Sobrino T, Labandeira-García JL, Nogueiras R, Domingos AI, Fernández-Real JM, Rahmouni K, Diéguez C, López M.

    Central nicotine induces browning through hypothalamic κ opioid receptor.

    Nat Commun. 2019 Sep 6;10(1):4037. doi: 10.1038/s41467-019-12004-z.


    Increased body weight is a major factor that interferes with smoking cessation.
    Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding and energy expenditure at the central level. Among the central actions of nicotine on body weight, much attention has been focused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue (WAT) is unclear. Here, we show that nicotine induces the browning of WAT through a central mechanism and that this effect is dependent on the κ opioid receptor (KOR), specifically in the lateral hypothalamic area (LHA). Consistent with these findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which correlates with smoking status. These data demonstrate that central nicotine-induced modulation of WAT browning may be a target against human obesity.

    Copyright 2021 Adipoplast
    • Home
    • About us
    • Research groups
    • Database
    • Contact
    Adipoplast